Quality and quantity of the humoral immune response in healthy elderly and young subjects after annually repeated influenza vaccination

被引:81
作者
de Bruijn, IA
Remarque, EJ
Jol-van der Zijde, CMJ
van Tol, MJD
Westendorp, RGJ
Knook, DL
机构
[1] Leiden Univ, Med Ctr, Sect Gerontol & Geriatr, Immunol Sect,Dept Paediat, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Clin Epidemiol Sect, NL-2300 RC Leiden, Netherlands
关键词
D O I
10.1086/314540
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Doubt about the serologic efficacy of annually repeated influenza vaccination prompted investigations into the course of hemagglutination-inhibiting (HI), IgG, and IgA antibody titers and the IgG and IgA avidity index to influenza A/Taiwan/1/86 and A/Beijing/353/89 after annual vaccination. Fifty-four healthy elderly persons >70 years of age and 24 healthy young adults <30 years of age received standard influenza vaccine during 3 consecutive years. On average, prevaccination HI, IgG, and IgA titers to both influenza virus strains increased greater than or equal to 4 fold between the first and the third vaccination (analysis of variance, P < .001), The postvaccination HI and IgG titers remained unchanged after annual vaccination. The avidity index of IgG and IgA antibodies increased somewhat after annual vaccination, although the increase was statistically significant only in the young subjects. These data indicate that annual influenza vaccination of healthy elderly and young subjects results in an overall increase in protective antibodies.
引用
收藏
页码:31 / 36
页数:6
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