Comparative genomics of the human and mouse T cell receptor loci

被引:137
作者
Glusman, G
Rowen, L
Lee, I
Boysen, C
Roach, JC
Smit, AFA
Wang, K
Koop, BF
Hood, L
机构
[1] Inst Syst Biol, Seattle, WA 98105 USA
[2] Paracel Inc, Pasadena, CA 91106 USA
[3] Phenogenom Corp, Bothell, WA 98021 USA
[4] Univ Victoria, Dept Biol, Victoria, BC V8W 3N5, Canada
关键词
D O I
10.1016/S1074-7613(01)00200-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The availability of the complete genomic sequences of the human and mouse T cell receptor loci opens up new opportunities for understanding T cell receptors (TCRs) and their genes. The full complement of TCR gene segments is finally known and should prove a valuable resource for supporting functional studies. A rational nomenclature system has been implemented and is widely available through IMGT and other public databases. Systematic comparisons of the genomic sequences within each locus, between loci, and across species enable precise analyses of the various diversification mechanisms and some regulatory signals. The genomic landscape of the TCR loci provides fundamental insights into TCR evolution as highly localized and tightly regulated gene families.
引用
收藏
页码:337 / 349
页数:13
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