Metal-induced apoptosis: mechanisms

被引：376

作者：

Pulido, Marisa D. ^{[1
]}

Parrish, Alan R. ^{[1
]}

机构：

[1] Texas A&M Univ, Coll Med, Dept Med Pharmacol & Toxicol, Syst Hlth Sci Ctr, College Stn, TX 77843 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2003年 / 533卷 / 1-2期

关键词：

Apoptosis; Arsenic; Cadmium; Chromium; Nickel; Beryllium;

D O I：

10.1016/j.mrfmmm.2003.07.015

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The past decade has seen an intense focus on mechanisms of apoptosis. Many important observations on the various signaling pathways mediating apoptotic cell death have been made and our understanding of the importance of apoptosis in both normal growth and development and pathophysiology has greatly increased. In addition, mechanisms of metal-induced toxicity continue to be of interest given the ubiquitous nature of these contaminants. The purpose of this review is to summarize our current understanding of the apoptotic pathways that are initiated by metals, mainly established (arsenic, cadmium, chromium, nickel, beryllium) and possible (lead, antimony, cobalt) human carcinogens. Increased understanding of metal-induced apoptosis is critical to illuminate mechanisms of metal-induced carcinogenesis, as well as the potential of metal species (arsenic) as chemotherapeutic agents. (C) 2003 Elsevier B.V. All rights reserved.

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页码：227 / 241

页数：15

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