Pointing in the right direction: new developments in the field of planar cell polarity

被引：90

作者：

Bayly, Roy ^{[1
]}

Axelrod, Jeffrey D. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

来源：

NATURE REVIEWS GENETICS | 2011年 / 12卷 / 06期

关键词：

GRAINY-HEAD; TRANSCRIPTION FACTOR; EPITHELIAL-CELLS; WING EPITHELIUM; XENOPUS-LAEVIS; BASAL BODIES; WOUND REPAIR; DROSOPHILA; CILIA; MORPHOGENESIS;

D O I：

10.1038/nrg2956

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, and have proposed new mechanistic models. However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.

引用

页码：385 / 391

页数：7

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