The structural requirement of phosphatidylinositols as substrate of phosphatidylinositol 3-kinase

被引：7

作者：

Shirai, R

Morita, K

Nishikawa, A

Nakatsu, N

Fukui, Y

Morisaki, N

Hashimoto, Y

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 09期

关键词：

carboxylic acids and derivatives; enzymes and enzyme reactions; inositols; phosphoric acids and derivatives;

D O I：

10.1016/S0040-4039(99)00004-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic distearate phosphatidylinositol (PI) was not phosphorylated by PI 3-kinase. The fatty acids at glycerol sn-2 must be as short as octanoic acid or less to act as a substrate of PI 3-kinase. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1693 / 1696

页数：4

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