Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes

被引：131

作者：

Choi, Ran ^{[1
]}

Kim, Bo Hwan ^{[2
]}

Naowaboot, Jarinyaporn ^{[1
]}

Lee, Mi Young ^{[1
]}

Hyun, Mi Ri ^{[3
]}

Cho, Eun Ju ^{[1
]}

Lee, Eun Soo ^{[1
]}

Lee, Eun Young ^{[3
]}

Yang, Young Chul

Chung, Choon Hee ^{[1
,4
]}

机构：

[1] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju 220701, South Korea

[2] Gachon Univ Med & Sci, Dept Nursing, Inchon 406799, South Korea

[3] Soonchunhyang Univ, Coll Med, Dept Internal Med, Cheonan 331090, South Korea

[4] Yonsei Univ, Wonju Coll Med, Inst Lifestyle Med, Wonju 220701, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2011年 / 43卷 / 12期

关键词：

diabetes mellitus; experimental; diabetic nephropathies; ferulic acid; inflammation; oxidative stress; SIGNALING PATHWAYS; OXIDATIVE STRESS; VITAMIN-C; TGF-BETA; EXPRESSION; MICE; ANTIOXIDANTS; DERIVATIVES; PODOCYTE; DISEASE;

D O I：

10.3858/emm.2011.43.12.078

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Diabetic nephropathy is the most serious complication in diabetes mellitus. It is known that oxidative stress and inflammation play a central role in the development of diabetic nephropathy. In this study, we investigated that ferulic acid (FA) known as anti-oxidative agent could effect on diabetic nephropathy by anti-oxidative and anti-inflammatory mechanism. We examined the effects of FA in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and non-diabetic control Long-Evans Tokushima Otsuka (LETO) rats. We treated FA to experimental rats from 26 to 45 weeks of age. We evaluated ACR, MDA and MCP-1 in 24 h urine and examined renal histopathology and morphologic change in extracted kidneys from rats. Also, we evaluated the ROS production and MCP-1 levels in cultured podocyte after FA treatment. In the FA-treated OLETF rats, blood glucose was significantly decreased and serum adiponectin levels were increased. Urinary ACR was significantly reduced in FA-treated OLETF rats compared with diabetic OLETF rats. In renal histopathology, FA-treated OLETF rats showed decreased glomerular basement membrane thickness, glomerular volume, and mesangial matrix expansion. FA treatment decreased oxidative stress markers and MCP-1 levels in 24 h urine of rats and supernatants of cultured podocyte. In conclusion, it was suggested that FA have protective and therapeutic effects on diabetic nephropathy by reducing oxidative stress and inflammation.

引用

页码：676 / 683

页数：8

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