The toxicology of interleukin-12: A review

被引：184

作者：

Car, BD ^{[1
]}

Eng, VM ^{[1
]}

Lipman, JM ^{[1
]}

Anderson, TD ^{[1
]}

机构：

[1] DuPont Pharmaceut Co, Stine Haskell Res Ctr, Safety Assessment, Newark, DE 19714 USA

来源：

TOXICOLOGIC PATHOLOGY | 1999年 / 27卷 / 01期

关键词：

interferon-gamma; mouse; guinea pig; squirrel monkey; cynomolgus macaque; chimpanzee; human; hematopoiesis; liver; intestine; lung; IL-12;

D O I：

10.1177/019262339902700112

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Recombinant murine interleukin (IL)-12 (rmIL-12) exhibits antitumor, antiviral, and antimicrobial activities and can modify allergic inflammatory reactions in animal models. Recombinant human IL-12 (rhIL-12) is currently in clinical trials for treatment of cancer, asthma. and viral hepatitis. Principally a phagocyte-derived cytokine, IL-12 targets natural killer cells and T lymphocytes, stimulating their activity and the secretion of interferon (IFN)-gamma. An understanding of the toxicology of IL-12, due in part to effects mediated by IFN-gamma, has emerged from preclinical safety and mechanistic studies and initial clinical trials. Target organs common to several animal species and humans include the lymphohematopoietic system, intestines, liver, and lung.

引用

页码：58 / 63

页数：6

共 62 条

[1] CHARACTERIZATION OF RECEPTORS FOR HUMAN-TUMOR NECROSIS FACTOR AND THEIR REGULATION BY GAMMA-INTERFERON [J].

AGGARWAL, BB ;

EESSALU, TE ;

HASS, PE .

NATURE, 1985, 318 (6047) :665-667

[2]

ANDERSON TD, 1993, INT REV EXP PATHOL A, V34, P58

[3]

Bajetta E, 1998, CLIN CANCER RES, V4, P75

[4]

Barbulescu K, 1998, J IMMUNOL, V160, P3642

[5]

BELLONE G, 1994, J IMMUNOL, V153, P930

[6] MULTIPLE EFFECTS ON PERIPHERAL HEMATOLOGY FOLLOWING ADMINISTRATION OF RECOMBINANT HUMAN INTERLEUKIN-12 TO NONHUMAN-PRIMATES [J].

BREE, AG ;

SCHLERMAN, FJ ;

KAVIANI, MD ;

HASTINGS, RC ;

HITZ, SL ;

GOLDMAN, SJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 204 (03) :1150-1157

[7] Antitumor activity of interleukin 12 in preclinical models [J].

Brunda, MJ ;

Luistro, L ;

Rumennik, L ;

Wright, RB ;

Dvorozniak, M ;

Aglione, A ;

Wigginton, JM ;

Wiltrout, RH ;

Hendrzak, JA ;

Palleroni, AV .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1996, 38 :S16-S21

[8]

CAR BD, 1995, AM J PATHOL, V147, P1693

[9] INDUCTION OF INTERFERON-GAMMA PRODUCTION BY NATURAL-KILLER-CELL STIMULATORY FACTOR - CHARACTERIZATION OF THE RESPONDER CELLS AND SYNERGY WITH OTHER INDUCERS [J].

CHAN, SH ;

PERUSSIA, B ;

GUPTA, JW ;

KOBAYASHI, M ;

POSPISIL, M ;

YOUNG, HW ;

WOLF, SF ;

YOUNG, D ;

CLARK, SC ;

TRINCHIERI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (04) :869-879

[10]

Chen L, 1997, J IMMUNOL, V159, P351

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