Polymer-supported membranes as models of the cell surface

被引：791

作者：

Tanaka, M ^{[1
]}

Sackmann, E ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Phys, D-85748 Garching, Germany

来源：

NATURE | 2005年 / 437卷 / 7059期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1038/nature04164

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lipid-bilayer membranes supported on solid substrates are widely used as cell-surface models that connect biological and artificial materials. They can be placed either directly on solids or on ultrathin polymer supports that mimic the generic role of the extracellular matrix. The tools of modern genetic engineering and bioorganic chemistry make it possible to couple many types of biomolecule to supported membranes. This results in sophisticated interfaces that can be used to control, organize and study the properties and function of membranes and membrane-associated proteins. Particularly exciting opportunities arise when these systems are coupled with advanced semiconductor technology.

引用

页码：656 / 663

页数：8

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