The distribution of estrogen receptor-beta mRNA in the rat hypothalamus

被引:247
作者
Shughrue, PJ
Komm, B
Merchenthaler, I
机构
[1] Women's Health Research Institute, Wyeth-Ayerst Research, Radnor, PA
[2] Women's Health Research Institute, Wyeth-Ayerst Research, Radnor, PA 19087
关键词
estrogen receptor-alpha; estrogen receptor-beta; ER; hypothalamus; in situ hybridization; steroid receptor; CENTRAL NERVOUS-SYSTEM; IMMUNOCYTOCHEMICAL LOCALIZATION; MONOCLONAL-ANTIBODIES; FEMALE RAT; BRAIN; CELLS;
D O I
10.1016/S0039-128X(96)00222-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recent cloning of a second form of the estrogen receptor (ER-beta) has made it possible to map the distribution of ER-beta mRNA-containing perikarya in the rat hypothalamus. The present in situ hybridization histochemical studies have detected ER-beta mRNA in the medial preoptic area; the anterior periventricular, paraventricular, supraoptic, arcuate, medial tuberal and medial mammillary nuclei; the bed nucleus of the stria terminalis, and zona incerta. As previously described for the classical ER (ER-alpha) mRNA, a dense accumulation of ER-beta mRNA-expressing perikarya is present in the medial preoptic area and bed nucleus of the stria terminalis. In contrast, ER-beta mRNA was also concentrated in the paraventricular and supraoptic nuclei, brain regions which contain little or no ER-alpha mRNA. Moreover, the arcuate and ventromedial nuclei, areas with abundant ER-alpha, contain only a weak level of ER-beta hybridization signal. The description of ER-beta mRNA-containing perikarya in the int hypothalamus provides a foundation for further morphological and physiological studies aimed at elucidating the role of ER-beta in the hypothalamus. (C) 1996 by Elsevier Science Inc.
引用
收藏
页码:678 / 681
页数:4
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