The Promise and Perils of Stem Cell Therapeutics

被引：207

作者：

Daley, George Q. ^{[1
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机构：

[1] Childrens Hosp Boston, Howard Hughes Med Inst, Stem Cell Transplantat Program, Div Pediat Hematol Oncol,Manton Ctr Orphan Dis Re, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[5] Broad Inst, Cambridge, MA 02142 USA

[6] Harvard Stem Cell Inst, Boston, MA 02138 USA

来源：

CELL STEM CELL | 2012年 / 10卷 / 06期

关键词：

UMBILICAL-CORD BLOOD; PANCREATIC BETA-CELLS; PARKINSONS-DISEASE; SPINAL-CORD; BONE-MARROW; DOPAMINE NEURONS; IN-VIVO; ISLET TRANSPLANTATION; CLINICAL-TRIALS; HUMAN ES;

D O I：

10.1016/j.stem.2012.05.010

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Stem cells are the seeds of tissue repair and regeneration and a promising source for novel therapies. However, apart from hematopoietic stem cell (HSC) transplantation, essentially all other stem cell treatments remain experimental. High hopes have inspired numerous clinical trials, but it has been difficult to obtain unequivocal evidence for robust clinical benefit. In recent years, unproven therapies have been widely practiced outside the standard clinical trial network, threatening the cause of legitimate clinical investigation. Numerous challenges and technical barriers must be overcome before novel stem cell therapies can achieve meaningful clinical impact.

引用

页码：740 / 749

页数：10

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