Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over

被引:86
作者
Bates, CJ
Pentieva, KD
Prentice, A
Mansoor, MA
Finch, S
机构
[1] MRC, Cambridge CB4 1XJ, England
[2] Social & Community Planning Res, London EC1V 0AX, England
[3] Cent Hosp Rogaland, Div Clin Chem, N-4003 Stavanger, Norway
关键词
vitamin B-6; pyridoxal phosphate; dietary survey; elderly;
D O I
10.1017/S0007114599000380
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Concentrations of pyridoxal phosphate and pyridoxic acid were measured in fasting plasma samples from British men and women aged 65 years and over, participating in a National Diet and Nutrition Survey during 1994-5, selected to be representative of the population of mainland Britain. In this population, the concentration of pyridoxal phosphate declined, whereas pyridoxic acid rose, with increasing age and frailty; however, both status indicators were strongly and directly (with a positive coefficient) correlated with estimates of vitamin B-6 intake. This was little affected by the inclusion of food energy and protein intakes in the model. Forty-eight percent of the participants living in the community and 75 % of those living in institutions had plasma pyridoxal phosphate concentrations below a range considered normal from other studies. In a univariate regression model, plasma pyridoxal phosphate concentrations were inversely correlated with plasma homocysteine concentrations, consistent with the hypothesis that vitamin B-6 status may influence plasma homocysteine levels, and hence vascular disease risk. However, this relationship was partly attenuated in a multiple regression model including age, sex, domicile and biochemical status indices, including those of folate and vitamin B-12. There was evidence that plasma pyridoxal phosphate was sensitive to metabolic conditions associated with inflammation and the acute-phase reaction, and that plasma pyridoxic acid was sensitive to renal function. Thus, neither index is an ideal predictor of vitamin B-6 status in older people, unless these confounding factors are allowed for. Since poor vitamin B-6 status may have health implications, e.g. for immune function, cognition, and for essential intermediary metabolic pathways in older people, it needs to be investigated as a possible public health problem.
引用
收藏
页码:191 / 201
页数:11
相关论文
共 47 条
  • [1] [Anonymous], 1998, National diet and nutrition survey: people aged 65 years and over
  • [2] [Anonymous], 1992, 43 DEP HLTH
  • [3] Relationships between micronutrient intake and biochemical indicators of nutrient adequacy in a 'free-living' elderly UK population
    Bailey, AL
    Maisey, S
    Southon, S
    Wright, AJA
    Finglas, PM
    Fulcher, RA
    [J]. BRITISH JOURNAL OF NUTRITION, 1997, 77 (02) : 225 - 242
  • [4] BATES CJ, 1997, EUR J CLIN NUTR, V51, P1
  • [5] Bates CJ, 1997, ANN CLIN BIOCHEM, V34, P1
  • [6] BATES CJ, 1998, IN PRESS CLIN CHIMIC
  • [7] A QUANTITATIVE ASSESSMENT OF PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR VASCULAR-DISEASE - PROBABLE BENEFITS OF INCREASING FOLIC-ACID INTAKES
    BOUSHEY, CJ
    BERESFORD, SAA
    OMENN, GS
    MOTULSKY, AG
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (13): : 1049 - 1057
  • [8] IMPAIRED HOMOCYSTEINE METABOLISM IN EARLY-ONSET CEREBRAL AND PERIPHERAL OCCLUSIVE ARTERIAL-DISEASE - EFFECTS OF PYRIDOXINE AND FOLIC-ACID TREATMENT
    BRATTSTROM, L
    ISRAELSSON, B
    NORRVING, B
    BERGQVIST, D
    THORNE, J
    HULTBERG, B
    HAMFELT, A
    [J]. ATHEROSCLEROSIS, 1990, 81 (01) : 51 - 60
  • [9] CHEN LH, 1981, INT J VITAM NUTR RES, V51, P232
  • [10] HOMOCYSTEINE AND CORONARY-ARTERY DISEASE IN FRENCH-CANADIAN SUBJECTS - RELATION WITH VITAMINS B-12, B-6, PYRIDOXAL-PHOSPHATE, AND FOLATE
    DALERY, K
    LUSSIERCACAN, S
    SELHUB, J
    DAVIGNON, J
    LATOUR, Y
    GENEST, J
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1995, 75 (16) : 1107 - 1111