Increased levels of magnetic iron compounds in Alzheimer's Disease

被引：6

作者：

Pankhurst, Quentin ^{[2
,3
]}

Hautot, Dimitri ^{[1
]}

Khan, Nadeem ^{[4
]}

Dobson, Jon ^{[1
]}

机构：

[1] Keele Univ, Inst Sci & Technol Med, Stoke On Trent ST4 7QB, Staffs, England

[2] UCL, London Ctr Nanotechnol, London WC1E 7HN, England

[3] UCL, Dept Phys & Astron, London WC1E 7HN, England

[4] Kings Coll London, Inst Psychiat, Dept Neuropathol, London SE5 8AF, England

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2008年 / 13卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A study of the magnetic properties of superior temporal gyrus brain tissue from 11 Alzheimer's disease (AD) and 11 age-matched control subjects demonstrates an exponential correlation between the concentrations of the Fe2+-ion-containing iron oxide, magnetite (Fe3O4), and the fraction of those particles that are smaller than 20 nm in diameter. These data provide circumstantial evidence in favor of their genesis within the 8 nm diameter cores of the iron storage protein ferritin. We also show, for the first time, that the total concentration of biogenic magnetite is generally higher in the AD brain (in some cases as much as 15 times greater than controls) and that there are gender-based differences, with AD female subjects having significantly higher concentrations than all other groups. These results provide insights which may guide current efforts to develop iron-based MRI diagnosis of AD.

引用

页码：49 / 52

页数：4

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