Effect of cation content of polycation-type gene carriers on in vitro gene transfer

被引：12

作者：

Yamaoka, T ^{[1
]}

Hamada, N

Iwata, H

Murakami, A

Kimura, Y

机构：

[1] Kyoto Inst Technol, Dept Polymer Sci & Engn, Sakyo Ku, Kyoto 6068585, Japan

[2] Natl Cardiovasc Ctr, Res Inst, Dept Surg Res, Suita, Osaka 565, Japan

来源：

CHEMISTRY LETTERS | 1998年 / 11期

关键词：

D O I：

10.1246/cl.1998.1171

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dextran-based polycations having different cation structures and contents were evaluated as carriers for transferring genes to mammalian cells in vitro. 2-(N, N-Dimethylamino)ethyl dextran having tertiary-amine-type cations induced very high transient gene expression in the COS-1 cells, while 2-aminoethyl dextran having primary-amine-type cations did not induced it at all. The cation content of the former was also found to affect the transient gene expression and the cytotoxicity of the polycations.

引用

页码：1171 / 1172

页数：2

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