Increased plasma levels of homocysteine and other thiol compounds in rheumatoid arthritis women

被引:75
作者
Hernanz, A
Plaza, A
Martín-Mola, E
De Miguel, E
机构
[1] Hosp Univ La Paz, Dept Biochem, Madrid, Spain
[2] Hosp Univ La Paz, Dept Rheumatol, Madrid 28046, Spain
关键词
homocysteine; thiol compounds; redox thiol status; rheumatoid arthritis;
D O I
10.1016/S0009-9120(98)00093-9
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objectives: Since moderate hyperhomocysteinemia is an independent risk factor for vascular disease and physiological thiol compounds mediate Cu2+- and Fe3+-dependent low-density lipoprotein (LDL) oxidation, we have studied the total plasma concentrations of thiol compounds including methionine as precursor of homocysteine in rheumatoid arthritis patients, in which the high mortality found is associated with cardiovascular disease. Design and methods: Thirty-eight women with rheumatoid arthritis and 25 age-matched control women were studied. Plasma was used to measure thiol compounds and amino acids by HPLC. Results: Rheumatoid arthritis patients showed significantly higher levels than healthy controls of total plasma homocysteine (17.3 +/- 7.8 vs. 7.6 +/- 1.9; p < 0.001), cysteine (293 +/- 61 vs. 201 +/- 45; p < 0.001), cysteinglycine (32.7 +/- 8.3 vs. 22.3 +/- 4.7; p < 0.001) and methionine (25 +/- 9 vs. 18 +/- 3; p < 0.01), whereas total glutathione levels were not increased (4.7 +/- 2.0 vs. 4.1 +/- 1.6). Conclusions: The increased levels of thiol compounds found in rheumatoid arthritis patients may be implicated in the increased incidence of cardiovascular disease found in these patients by means of the toxic effect of homocysteine on endothelium and the increased susceptibility of LDL to oxidation by increased plasma amounts of thiol compounds such as cysteine. Copyright (C) 1999 The Canadian Society of Clinical Chemists.
引用
收藏
页码:65 / 70
页数:6
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