Development of inflammatory hypersensitivity and augmentation of sodium channels in rat dorsal root ganglia

被引:31
作者
Gould, HJ
Gould, TN
Paul, D
England, JD
Liu, ZP
Reeb, SC
Levinson, SR
机构
[1] Louisiana State Univ, Med Ctr, Dept Neurol, New Orleans, LA 70112 USA
[2] Univ Colorado, Sch Med, Dept Physiol, Denver, CO USA
关键词
sodium channel augmentation; inflammation; pain; dorsal root ganglia;
D O I
10.1016/S0006-8993(99)01218-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The development of thermal allodynia in relationship to sodium channel augmentation in dorsal root ganglia (DRGs) was studied in albino rats. Paw withdrawal latencies were measured hourly following complete Freund's adjuvant (CFA) injections. Sodium channels were demonstrated with immunocytochemistry. Sustained minimum latencies were attained between 10 and 12 h post-injection, Sodium channel labeling began to increase at 23 h post-injection and reached maximum levels by 24 h. Thermal hypersensitivity is thus established 12 h before sodium channel augmentation can be demonstrated. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:296 / 299
页数:4
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