The Striatum and Pain Modulation

被引：65

作者：

Barcelo, Ana C. ^{[2
]}

Filippini, Barbara ^{[1
]}

Pazo, Jorge H. ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Med, Dept Fisiol, Lab Neurofisiol, RA-1121 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Odontol, Catedra Fisiol, RA-1121 Buenos Aires, DF, Argentina

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2012年 / 32卷 / 01期

关键词：

Basal ganglia; Striatum; Orofacial pain; Jaw opening reflex; Sensorial trigeminal nuclei; Endogenous analgesic system; Indirect pathway; Electrical stimulation; Chemical stimulation; TRIGEMINAL SUBNUCLEUS CAUDALIS; JAW-OPENING REFLEX; FOS-LIKE IMMUNOREACTIVITY; MEDULLARY DORSAL-HORN; NUCLEUS RAPHE MAGNUS; D2; RECEPTOR-BINDING; TOOTH-PULP; BASAL GANGLIA; NOCICEPTIVE RESPONSES; BRAIN-STEM;

D O I：

10.1007/s10571-011-9737-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The aim of this review was to give a general aspect of the sensorial function of the striatum related to pain modulation, which was intensively studied in our laboratory. We analyse the effect of electrical and chemical stimulation of the striatum on the orofacial pain, especially that produced by tooth pulp stimulation of the lower incisors. We demonstrated specific sites within the nucleus which electrical or chemical stimulation produced inhibition of the nociceptive jaw opening reflex. This analgesic action of the striatum was mediated by activation of its dopamine D-2 receptors and transmitted through the indirect pathways of the basal ganglia and the medullary dorsal reticular nucleus (RVM) to the sensorial nuclei of the trigeminal nerve. Its mechanism of action was by inhibition of the nociceptive response of the second order neurons of the nucleus caudalis of the V par.

引用

页码：1 / 12

页数：12

共 86 条

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