Rapid Pneumococcal Evolution in Response to Clinical Interventions

被引：683

作者：

Croucher, Nicholas J. ^{[1
]}

Harris, Simon R. ^{[1
]}

Fraser, Christophe ^{[2
]}

Quail, Michael A. ^{[1
]}

Burton, John ^{[1
]}

van der Linden, Mark ^{[3
]}

McGee, Lesley ^{[4
]}

von Gottberg, Anne ^{[5
,6
]}

Song, Jae Hoon ^{[7
,8
]}

Ko, Kwan Soo ^{[9
]}

Pichon, Bruno ^{[10
]}

Baker, Stephen ^{[11
]}

Parry, Christopher M. ^{[11
]}

Lambertsen, Lotte M. ^{[12
]}

Shahinas, Dea ^{[13
,14
]}

Pillai, Dylan R. ^{[13
,14
]}

Mitchell, Timothy J. ^{[15
]}

Dougan, Gordon ^{[1
]}

Tomasz, Alexander ^{[16
]}

Klugman, Keith P. ^{[4
,5
,6
,17
,18
]}

Parkhill, Julian ^{[1
]}

Hanage, William P. ^{[2
,19
]}

Bentley, Stephen D. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London W2 1PG, England

[3] Rhein Westfal TH Aachen, Univ Hosp, Inst Med Microbiol, Natl Reference Ctr Streptococci, D-52074 Aachen, Germany

[4] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA

[5] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Resp & Meningeal Pathogens Res Unit, ZA-2000 Johannesburg, South Africa

[6] Univ Witwatersrand, ZA-2000 Johannesburg, South Africa

[7] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea

[8] Asia Pacific Fdn Infect Dis, Seoul, South Korea

[9] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon 440746, South Korea

[10] Hlth Protect Agcy Ctr Infect, Resp & Syst Infect Lab, London NW9 5HT, England

[11] Oxford Univ Clin Res Unit, Wellcome Trust Major Overseas Programme, Hosp Trop Dis, Ho Chi Minh City, Vietnam

[12] Statens Serum Inst, Dept Microbiol Surveillance & Res, DK-2300 Copenhagen S, Denmark

[13] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1V2, Canada

[14] Ontario Agcy Hlth Protect & Promot, Toronto, ON M5G 1V2, Canada

[15] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow G12 8TA, Lanark, Scotland

[16] Rockefeller Univ, Microbiol Lab, New York, NY 10021 USA

[17] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA

[18] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA 30322 USA

[19] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

SCIENCE | 2011年 / 331卷 / 6016期

基金：

英国惠康基金;

关键词：

RESISTANT STREPTOCOCCUS-PNEUMONIAE; ANTIBIOTIC-RESISTANCE; INTERCONTINENTAL SPREAD; UNITED-STATES; SEROTYPE; 19A; 23F CLONE; EMERGENCE; DISEASE; TRANSFORMATION; SEQUENCE;

D O I：

10.1126/science.1198545

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polymorphisms arising through horizontal sequence transfer. More than 700 recombinations were detected, with genes encoding major antigens frequently affected. Among these were 10 capsule-switching events, one of which accompanied a population shift as vaccine-escape serotype 19A isolates emerged in the USA after the introduction of the conjugate polysaccharide vaccine. The evolution of resistance to fluoroquinolones, rifampicin, and macrolides was observed to occur on multiple occasions. This study details how genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinical interventions over remarkably short time scales.

引用

页码：430 / 434

页数：5

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