A prospective open study of the efficacy of high-dose recombinant hepatitis B rechallenge vaccination in HIV-infected patients

被引：55

作者：

de Vries-Sluijs, Theodora E. M. S. ^{[1
]}

Hansen, Bettina E. ^{[2
,3
]}

van Doornum, Gerard J. J. ^{[4
]}

Springeling, Tirza ^{[1
]}

Evertsz, Nicole M. ^{[1
]}

de Man, Robert A. ^{[3
]}

van der Ende, Marchina E. ^{[1
]}

机构：

[1] Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Infect Dis Sect, NL-3015 CE Rotterdam, Netherlands

[2] Erasmus MC, Dept Epidemiol & Biostat, Rotterdam, Netherlands

[3] Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands

[4] Erasmus MC, Dept Virol, Rotterdam, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 02期

关键词：

D O I：

10.1086/524690

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Double-dose hepatitis B virus revaccination of human immunodeficiency virus (HIV) -infected patients proved to be effective in 50.7% of 144 patients who had previously failed to respond to standard doses. In the multivariate analysis, female patients were found to have a significantly better response (P = .03). The effect of age on the response depended on the viral load at the time of revaccination. For patients with a detectable HIV RNA load, the effect of age was stronger (odds ratio [ OR], 0.34 per 10 years older [ 95% confidence interval {CI}, 0.16-0.72]; P = .005) than for patients with an undetectable HIV RNA load (OR, 0.74 per 10 years older [ 95% CI, 0.50-1.09]; P = .12).

引用

页码：292 / 294

页数：3

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