The meaning and impact of the human genome sequence for microbiology

被引：92

作者：

Relman, DA ^{[1
]}

Falkow, S

机构：

[1] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[2] Vet Affairs Hlth Care Syst, Palo Alto, CA 94304 USA

来源：

TRENDS IN MICROBIOLOGY | 2001年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0966-842X(01)02041-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The characterization of life is immeasurably enhanced by determination of complete genome sequences. For organisms that engage in intimate interactions with others, the genome sequence from one participant, and associated tools, provide unique insight into its partner. We discuss how the human genome sequence will further our understanding of microbial pathogens and commensals, and vice versa. We also propose criteria for implicating a host gene in microbial pathogenesis, and urge consideration of a 'second human genome project'.

引用

页码：206 / 208

页数：3

共 23 条

[1] Singular value decomposition for genome-wide expression data processing and modeling [J].

Alter, O ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :10101-10106

[2] The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies [J].

Belcher, CE ;

Drenkow, J ;

Kehoe, B ;

Gingeras, TR ;

McNamara, N ;

Lemjabbar, H ;

Basbaum, C ;

Relman, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (25) :13847-13852

[3] Knowledge-based analysis of microarray gene expression data by using support vector machines [J].

Brown, MPS ;

Grundy, WN ;

Lin, D ;

Cristianini, N ;

Sugnet, CW ;

Furey, TS ;

Ares, M ;

Haussler, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (01) :262-267

[4] Exploring the new world of the genome with DNA microarrays [J].

Brown, PO ;

Botstein, D .

NATURE GENETICS, 1999, 21 (Suppl 1) :33-37

[5] Cellular microbiology emerging [J].

Cossart, P ;

Boquet, P ;

Normark, S ;

Rappuoli, R .

SCIENCE, 1996, 271 (5247) :315-316

[6] Using DNA microarrays to study host-microbe interactions [J].

Cummings, CA ;

Relman, DA .

EMERGING INFECTIOUS DISEASES, 2000, 6 (05) :513-525

[7] Comparing functional genomic datasets: lessons from DNA. microarray analyses of host-pathogen interactions [J].

Diehn, M ;

Relman, DA .

CURRENT OPINION IN MICROBIOLOGY, 2001, 4 (01) :95-101

[8] Cluster analysis and display of genome-wide expression patterns [J].

Eisen, MB ;

Spellman, PT ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868

[9] A genomic view of immunology [J].

Fahrer, AM ;

Bazan, JF ;

Papathanasiou, P ;

Nelms, KA ;

Goodnow, CC .

NATURE, 2001, 409 (6822) :836-838

[10]

FALKOW S, 1988, REV INFECT DIS, V10, pS274

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