The neurotensin receptor antagonist SR 48692, decreases extracellular striatal GABA in rats

被引：8

作者：

Chapman, MA

See, RE

机构：

[1] WASHINGTON STATE UNIV, DEPT PSYCHOL, PULLMAN, WA 99164 USA

[2] WASHINGTON STATE UNIV, PROGRAM NEUROSCI, PULLMAN, WA 99164 USA

来源：

BRAIN RESEARCH | 1996年 / 729卷 / 01期

关键词：

neurotensin; microdialysis; GABA; glycine; SR; 45692; rat;

D O I：

10.1016/S0006-8993(96)00407-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracranial microdialysis was utilized to assess the effects of the novel neurotensin antagonist SR 48692 on extracellular gamma-amino-butyric acid (GABA) and glycine in the striatum. Subcutaneous injection of SR 48692 (0.2 mg/kg) significantly decreased extracellular striatal GABA levels, with peak decreases occurring 2-3 h post-injection. Injection of SR 48692 had no significant effect on glycine levels. These data suggest that endogenous neurotensin may modulate striatal GABA levels.

引用

页码：124 / 126

页数：3

共 18 条

[1] HIGH-SENSITIVITY HPLC ASSAY FOR GABA IN BRAIN DIALYSIS STUDIES
BOURDELAIS, A
KALIVAS, PW
[J]. JOURNAL OF NEUROSCIENCE METHODS, 1991, 39 (02) : 115 - 121
[2] BRUN P, 1995, J NEUROCHEM, V64, P2073
[3] NEUROTENSIN INCREASES EXTRACELLULAR STRIATAL DOPAMINE LEVELS INVIVO
CHAPMAN, MA
SEE, RE
BISSETTE, G
[J]. NEUROPEPTIDES, 1992, 22 (03) : 175 - 183
[4] INTERACTIONS OF NEUROTENSIN WITH DOPAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS-SYSTEM
ERVIN, GN
NEMEROFF, CB
[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1988, 12 : S53 - S69
[5] INTRAMEMBRANE INTERACTIONS BETWEEN NEUROTENSIN RECEPTORS AND DOPAMINE D(2)-RECEPTORS AS A MAJOR MECHANISM FOR THE NEUROLEPTIC-LIKE ACTION OF NEUROTENSIN
FUXE, K
VONEULER, G
AGNATI, LF
PICH, EM
OCONNOR, WT
TANGANELLI, S
LI, XM
TINNER, B
CINTRA, A
CARANI, C
BENFENATI, F
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1992, 668 : 186 - 204
[6] BIOCHEMICAL AND PHARMACOLOGICAL PROFILE OF A POTENT AND SELECTIVE NONPEPTIDE ANTAGONIST OF THE NEUROTENSIN RECEPTOR
GULLY, D
CANTON, M
BOIGEGRAIN, R
JEANJEAN, F
MOLIMARD, JC
PONCELET, M
GUEUDET, C
HEAULME, M
LEYRIS, R
BROUARD, A
PELAPRAT, D
LABBEJULLIE, C
MAZELLA, J
SOUBRIE, P
MAFFRAND, JP
ROSTENE, W
KITABGI, P
LEFUR, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) : 65 - 69
[7] AUTORADIOGRAPHIC AND ELECTROPHYSIOLOGICAL EVIDENCE FOR THE EXISTENCE OF NEUROTENSIN RECEPTORS ON CULTURED ASTROCYTES
HOSLI, E
STAUFFER, S
HOSLI, L
[J]. NEUROSCIENCE, 1995, 66 (03) : 627 - 633
[8] ANTIPARKINSON-LIKE EFFECTS OF NEUROTENSIN IN 6-HYDROXYDOPAMINE LESIONED RATS
JOLICOEUR, FB
RIVEST, R
STPIERRE, S
DRUMHELLER, A
[J]. BRAIN RESEARCH, 1991, 538 (02) : 187 - 192
[9] REGULATION OF NEUROTENSIN-CONTAINING NEURONS IN THE RAT STRIATUM - EFFECTS OF UNILATERAL STRIATAL LESIONS WITH QUINOLINIC ACID AND IBOTENIC ACID ON NEUROTENSIN CONTENT AND ITS BINDING-SITE DENSITY
MASUO, Y
MONTAGNE, MN
PELAPRAT, D
SCHERMAN, D
ROSTENE, W
[J]. BRAIN RESEARCH, 1990, 520 (1-2) : 6 - 13
[10] A RAPID ASSAY FOR NEUROTRANSMITTER AMINO-ACIDS, ASPARTATE, GLUTAMATE, GLYCINE, TAURINE AND GAMMA-AMINOBUTYRIC-ACID IN THE BRAIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION
MURAI, S
SAITO, H
ABE, E
MASUDA, Y
ITOH, T
[J]. JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1992, 87 (02) : 145 - 153

← 1 2 →