Signature-tagged mutagenesis in the identification of virulence genes in pathogens

被引：57

作者：

Shea, JE ^{[1
]}

Santangelo, JD ^{[1
]}

Feldman, RG ^{[1
]}

机构：

[1] Microsci Ltd, Wokingham RG41 5TU, Berks, England

来源：

CURRENT OPINION IN MICROBIOLOGY | 2000年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(00)00120-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Signature-tagged mutagenesis is a functional genomics technique that identifies microbial genes required for infection within an animal host, or within host cells. The application of this technique to a range of microbial pathogens has resulted in the identification of novel virulence determinants in each screen performed to date, so that cumulatively several hundred genes have been ascribed a role in virulence.

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页码：451 / 458

页数：8

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