A new highly enantioselective synthesis of both (R)- and (S)-2-mercaptosuccinic acids

被引：11

作者：

Chen, BC ^{[1
]}

Bednarz, MS ^{[1
]}

Kocy, OR ^{[1
]}

Sundeen, JE ^{[1
]}

机构：

[1] Bristol Myers Squibb Pharmaceut Res Inst, Discovery Chem, Princeton, NJ 08543 USA

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(98)00149-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(R)- and (S)-2-Mercaptosuccinic acids 4 were prepared in five steps in >96% ee and 49-52% overall yield via a new efficient synthesis starting from commercially available L- and D-aspartic acids. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1641 / 1644

页数：4

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