Development of a T1 contrast agent for magnetic resonance imaging using MnO nanoparticles

被引：523

作者：

Na, Hyon Bin

Lee, Jung Hee ^{[1
]}

An, Kwangjin

Park, Yong Il

Park, Mihyun

Lee, In Su

Nam, Do-Hyun

Kim, Sung Tae

Kim, Seung-Hoon

Kim, Sang-Wook

Lim, Keun-Ho

Kim, Ki-Soo

Kim, Sun-Ok

Hyeon, Taeghwan

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul 135710, South Korea

[2] Seoul Natl Univ, Sch Chem & Biol Engn, Natl Creat Res Initiat Ctr Oxide Oxide N, Seoul 151744, South Korea

[3] Kyung Hee Univ, Dept Chem & Adv Mat Sci, Yongin 446701, South Korea

[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg, Seoul 135710, South Korea

[5] Ajou Univ, Dept Mol Sci & Technol, Suwon 443749, South Korea

[6] Univ Ulsan, Asan Inst Life Sci, NMR Lab, Seoul 138736, South Korea

[7] Univ Ulsan, Asan Inst Life Sci, NMR Lab, Seoul 138736, South Korea

[8] Univ Ulsan, Asan Med Ctr, Dept Pediat, Seoul 138736, South Korea

[9] Samyang R&D Ctr, Taejon 305717, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 28期

关键词：

contrast agents; imaging agents magnetic; resonance imaging; manganese; nanoparticles;

D O I：

10.1002/anie.200604775

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Contrasting images: A new T1 contrast agent for magnetic resonance imaging (MRI) based on MnO nanoparticles reveals a bright signal enhancement and fine anatomic structures in the T1-weighted MR image of a mouse brain (see picture; left MRI, right MnO-enhanced MRI (MONEMRI)). Furthermore, MnO nanoparticles conjugated with a tumor-specific antibody were used for selectively imaging breast cancer cells in a metastatic tumor in brain. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5397 / 5401

页数：5

共 66 条

[1] The use of nanocrystals in biological detection [J].