Proton magnetic resonance spectroscopy of the brain in three cases of Rett syndrome: comparison with autism and normal controls

被引：24

作者：

Hashimoto, T

Kawano, N

Fukuda, K

Endo, S

Mori, K

Yoneda, Y

Yamaue, T

Harada, M

Miyoshi, K

机构：

[1] Natl Ctr Hosp Mental Nervous & Muscular Disorders, NCNP, Dept Child Neurol, Kodaira, Tokyo, Japan

[2] Higashi Tokushima Hosp, Natl Sanatorium, Dept Pediat, Tokushima, Japan

[3] Natl Kagawa Childrens Hosp, Dept Pediat, Kagawa, Japan

[4] Univ Tokushima, Sch Med Sci, Dept Radiol Technol, Tokushima 770, Japan

[5] Univ Tokushima, Sch Med, Dept Pediat, Tokushima 770, Japan

[6] Univ Tokushima, Sch Med, Dept Radiol, Tokushima 770, Japan

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1998年 / 98卷 / 01期

关键词：

(1)H-MRS; Rett syndrome; N-acetylaspartate;

D O I：

10.1111/j.1600-0404.1998.tb07371.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Rett syndrome (RS) is a clinically defined disorder characterized by autistic behavior, and cognitive and motor skill loss early in life. We performed (1)H-MRS of the brain in 3 cases of RS in comparison with in autism and controls. The older patient with RS demonstrated decreased N-acetylaspartate (NAA)/choline (Cho) and NAA/creatine (Cr) ratios when compared with the autism and control groups, whereas the younger patients did not demonstrate these decreased metabolite ratios. The Cho/Cr ratio did not differ among Rett syndrome, autism and controls. Since the clinical stage did not differ among the 3 cases of RS, it was suggested that NAA was decreased with increasing age and was not related with the clinical stage of RS. The NAA/Cho, NAA/Cr and Cho/Cr ratios did not differ between autism and controls. The present data suggest that there may be a secondary degenerative process of late onset in RS, which pathophysiologically differs from autism.

引用

页码：8 / 14

页数：7

共 37 条

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