The immunoglobulin E allergen interaction: A target for therapy of type I allergic diseases

被引：28

作者：

Valenta, R

Almo, S

Ball, T

Dolecek, C

Steinberger, P

Laffer, S

Eibensteiner, P

Flicker, S

Vrtala, S

Spitzauer, S

Valent, P

Denepoux, S

Kraft, D

Banchereau, J

Lebecque, S

机构：

[1] Univ Vienna, Sch Med, Vienna Gen Hosp, Dept Gen & Expt Pathol, A-1090 Vienna, Austria

[2] Univ Vienna, Inst Med & Chem Lab Diagnost, Vienna, Austria

[3] Univ Vienna, Dept Internal Med 1, AKH, Div Hematol, Vienna, Austria

[4] Schering Plough Corp, Lab Immunol Res, Dardilly, France

[5] Albert Einstein Coll Med, Dept Biochem, New York, NY USA

[6] Baylor Inst Immunol, Dallas, TX USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1998年 / 116卷 / 03期

关键词：

type I allergy; immunoglobulin E; recombinant allergens; blocking antibody; immunotherapy;

D O I：

10.1159/000023942

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leads in sensitized individuals through effector cell activation to the immediate induction of a cascade of inflammatory reactions, the hallmark of type I allergy. Recently, the molecular and structural characterization of allergens, specific IgE antibodies and their epitopes has made rapid progress. Here we discuss active and passive strategies for therapy of type I allergy, which are based on interfering with the IgE-allergen interaction.

引用

页码：167 / 176

页数：10

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