Total synthesis of the antipode of alkaloid 205 B

被引：37

作者：

Toyooka, N ^{[1
]}

Fukutome, A ^{[1
]}

Shinoda, H ^{[1
]}

Nemoto, H ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 32期

关键词：

alkaloids; Michael addition; natural products; nitrogen heterocycles; stereoelectronic effects;

D O I：

10.1002/anie.200351906

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Forming the tetrasubstituted piperidine ring with stereocontrol in a Michael-type conjugate addition is a key step in the first enantioselective synthesis of the antipode 1 of alkaloid 205 B. The absolute stereo-chemistry of the natural product could be determined unambiguously by comparison of the optical rotations.

引用

页码：3808 / 3810

页数：3

共 31 条

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