Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain

被引：304

作者：

Kim, DK ^{[1
]}

Zhang, Y

Kehr, J

Klason, T

Bjelke, B

Muhammed, M

机构：

[1] Royal Inst Technol, Mat Chem Div, SE-10044 Stockholm, Sweden

[2] Karolinska Inst, Div Cellular & Mol Neurochem, SE-17177 Stockholm, Sweden

[3] Karolinska Inst, Expt Unit, MRI Ctr, SE-17176 Stockholm, Sweden

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2001年 / 225卷 / 1-2期

基金：

瑞典研究理事会;

关键词：

nanoparticles; superparamagnetism; MRI; iron oxide; brain; rat; contrast agent;

D O I：

10.1016/S0304-8853(00)01255-5

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A pre-clinical study has been carried out for the utilization of magnetite (Fe-3 O-4) nanoparticles as a diagnostic tracer for MRI. Surfactant-coated Fe3O4 nanoparticles have been synthesized by a chemical coprecipitation method with a narrow particle size of around 6 nm. Preliminary experiments demonstrated the feasibility of using superparamagnetic Fe-3 O-4 nanoparticles as contrast agents in MR imaging. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：256 / 261

页数：6

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