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Novel dephosphotetrahydromethanopterin biosynthesis genes discovered via mutagenesis in Methylobacterium extorquens AM1

被引：16
作者：
Chistoserdova, L
Rasche, ME
Lidstrom, ME
机构：
[1] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA
[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
[3] Univ Florida, Dept Microbiol & Cell Sci, Gainesville, FL 32611 USA
来源：
JOURNAL OF BACTERIOLOGY | 2005年 / 187卷 / 07期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1128/JB.187.7.2508-2512.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Methylobacterium extorquens AM1 was used to explore the genetics of dephosphotetrahydromethanopterin (dH(4)MPT) biosynthesis. Strains with mutations in eight "archaeal-type" genes linked on the chromosome of M. extorquens AM1 were analyzed for the ability to synthesize dH(4)MPT, and six were found to be dH(4)MPT negative. Putative functions of these genes in dH(4)MPT biosynthesis are discussed.
引用
收藏
页码：2508 / 2512
页数：5
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