Enantiomeric visualization using proton-decoupled natural abundance deuterium NMR in poly(γ-benzyl-L-glutamate) liquid crystalline solutions

被引：75

作者：

Lesot, P ^{[1
]}

Merlet, D

Loewenstein, A

Courtieu, J

机构：

[1] Univ Paris Sud, Chim Organ Struct Lab, ICMO, CNRS,URA 1384, F-91405 Orsay, France

[2] Technion Israel Inst Technol, Dept Chem, IL-32000 Haifa, Israel

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(98)00179-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report the first visualization of chiral molecules oriented in a polypeptide liquid crystalline system (PBLG) using proton-decoupled natural abundance deuterium NMR. The chiral discrimination is observed through measurements of the quadrupolar splitting differences and we demonstrate that the sensitivity of natural abundance deuterium NMR is sufficient to measure the differential ordering effects (DOEs) without the need for isotopic enrichment. The feasibility and the potential of this novel method were investigated using a 5.87 T spectrometer (proton frequency 250 MHz). Several examples of chiral discrimination are presented and particular emphasis is given to demonstrate the potential of this approach. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1871 / 1881

页数：11

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