Tunable antibodies

被引:41
作者
Weiner, LM
Carter, P
机构
[1] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
[2] Seattle Genet Corp, Bothell, WA 98021 USA
关键词
D O I
10.1038/nbt0505-556
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A recent Keystone meeting highlighted the progress in generating effective anti-cancer antibodies by manipulating antibody binding affinity and their ability to support ADCC.
引用
收藏
页码:556 / 557
页数:2
相关论文
共 9 条
[1]  
Adams GP, 2001, CANCER RES, V61, P4750
[2]   Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene [J].
Cartron, G ;
Dacheux, L ;
Salles, G ;
Solal-Celigny, P ;
Bardos, P ;
Colombat, P ;
Watier, H .
BLOOD, 2002, 99 (03) :754-758
[3]  
Colby DW, 2004, METHOD ENZYMOL, V388, P348
[4]   Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37°C [J].
Graff, CP ;
Chester, K ;
Begent, R ;
Wittrup, KD .
PROTEIN ENGINEERING DESIGN & SELECTION, 2004, 17 (04) :293-304
[5]   Isolation of picomolar affinity Anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site [J].
Schier, R ;
McCall, A ;
Adams, GP ;
Marshall, KW ;
Merritt, H ;
Yim, M ;
Crawford, RS ;
Weiner, LM ;
Marks, C ;
Marks, JD .
JOURNAL OF MOLECULAR BIOLOGY, 1996, 263 (04) :551-567
[6]   Yeast mating for combinatorial Fab library generation and surface display [J].
Weaver-Feldhaus, JM ;
Lou, JL ;
Coleman, JR ;
Siegel, RW ;
Marks, JD ;
Feldhaus, MJ .
FEBS LETTERS, 2004, 564 (1-2) :24-34
[7]   THE PHARMACOLOGY OF MONOCLONAL-ANTIBODIES [J].
WEINSTEIN, JN ;
EGER, RR ;
COVELL, DG ;
BLACK, CDV ;
MULSHINE, J ;
CARRASQUILLO, JA ;
LARSON, SM ;
KEENAN, AM .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 507 :199-210
[8]   Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma [J].
Weng, WK ;
Levy, R .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (21) :3940-3947
[9]  
2005, KEYST S ANT BAS THER