Sirtuins and β-cell function

被引：15

作者：

Bordone, L.

Guarente, L.

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Novartis Inst BioMed Res, Dept Diabet & Metab, Cambridge, MA USA

来源：

DIABETES OBESITY & METABOLISM | 2007年 / 9卷

关键词：

beta-cells; calorie restriction; insulin secretion; SIRT1; SIRT4;

D O I：

10.1111/j.1463-1326.2007.00769.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over the past century, there have been major advances in medicine, diet and living conditions that have substantially extended the health span of people in the developed world. Over the past decade or so, the science of ageing has made great strides in providing an understanding of the underlying causes of ageing and how diet and genes play into the ageing process. In this essay, we will review some of the recent advances made in the science of sirtuins and beta-cell biology, and discuss how we will apply this knowledge to further the progress of humankind in healthy ageing.

引用

页码：23 / 27

页数：5

共 18 条

[1] Resveratrol improves health and survival of mice on a high-calorie diet
Baur, Joseph A.
Pearson, Kevin J.
Price, Nathan L.
Jamieson, Hamish A.
Lerin, Carles
Kalra, Avash
Prabhu, Vinayakumar V.
Allard, Joanne S.
Lopez-Lluch, Guillermo
Lewis, Kaitlyn
Pistell, Paul J.
Poosala, Suresh
Becker, Kevin G.
Boss, Olivier
Gwinn, Dana
Wang, Mingyi
Ramaswamy, Sharan
Fishbein, Kenneth W.
Spencer, Richard G.
Lakatta, Edward G.
Le Couteur, David
Shaw, Reuben J.
Navas, Placido
Puigserver, Pere
Ingram, Donald K.
de Cabo, Rafael
Sinclair, David A.
[J]. NATURE, 2006, 444 (7117) : 337 - 342
[2] Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
Bordone, L
Motta, MC
Picard, F
Robinson, A
Jhala, US
Apfeld, J
McDonagh, T
Lemieux, M
McBurney, M
Szilvasi, A
Easlon, EJ
Lin, SJ
Guarente, L
[J]. PLOS BIOLOGY, 2006, 4 (02): : 210 - 220
[3] Calorie restriction, SIRT1 and metabolism: Understanding longevity
Bordone, L
Guarente, L
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) : 298 - 305
[4] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A
Sweeney, LB
Sturgill, JF
Chua, KF
Greer, PL
Lin, YX
Tran, H
Ross, SE
Mostoslavsky, R
Cohen, HY
Hu, LS
Cheng, HL
Jedrychowski, MP
Gygi, SP
Sinclair, DA
Alt, FW
Greenberg, ME
[J]. SCIENCE, 2004, 303 (5666) : 2011 - 2015
[5] Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
Frye, RA
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 260 (01) : 273 - 279
[6] Sirtuins as potential targets for metabolic syndrome
Guarente, Leonard
[J]. NATURE, 2006, 444 (7121) : 868 - 874
[7] Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S
Armstrong, CM
Kaeberlein, M
Guarente, L
[J]. NATURE, 2000, 403 (6771) : 795 - 800
[8] The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
Kaeberlein, M
McVey, M
Guarente, L
[J]. GENES & DEVELOPMENT, 1999, 13 (19) : 2570 - 2580
[9] FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction
Kitamura, YI
Kitamura, T
Kruse, JP
Raum, JC
Stein, R
Gu, W
Accili, D
[J]. CELL METABOLISM, 2005, 2 (03) : 153 - 163
[10] How does calorie restriction work?
Koubova, J
Guarente, L
[J]. GENES & DEVELOPMENT, 2003, 17 (03) : 313 - 321

← 1 2 →