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Intestinal epithelial TOLLerance versus inTOLLerance of commensals

被引：96
作者：
Cario, E
Podolsky, DK
机构：
[1] Univ Hosp Essen, Div Gastroenterol & Hepatol, D-45157 Essen, Germany
[2] Harvard Univ, Sch Med, Gastrointestinal Unit, MGH,Ctr Study Inflammatory Bowel Dis, Boston, MA USA
来源：
MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 08期
关键词：
host-microbe interactions; intestinal epithelium; innate immunity; Toll-like receptor; tolerance;
D O I：
10.1016/j.molimm.2004.12.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This brief review summarizes the current understanding of Toll-like receptor (TLRs) mediated intestinal epithelial mechanisins of commensal tolerance versus intolerance and provides an update on the downstream ne,gative control of signaling responses through decreased surface expression, interregulation with NOD2, overexpression of Tollip, various inhibitors of NF-kappa B as well as Soluble tolerizing mediators present in lumen and serum which all may maintain or-when dysregulated-impair mucosal homeostasis in health or disease, respectively. (c) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：887 / 893
页数：7
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