Mode of action of bi- and trinuclear zinc hydrolases and their synthetic analogues

被引：278

作者：

Weston, J ^{[1
]}

机构：

[1] Univ Jena, Inst Organ & Makromol Chem, D-07743 Jena, Germany

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 06期

关键词：

D O I：

10.1021/cr020057z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The mode of action of bi- and trinuclear zinc hydrolases and their synthetic analogues are reviewed. Countless hydrolysis reactions are performed efficiently and selectively in biological systems through the interplay of two or three divalent metal ions in the active site of an enzyme. Topics covered include phosphate ester hydrolysis, metallo-β-lactamases, metallo-aminopeptidases, and biomimetic models based on bi- and tri-zinc cores.

引用

页码：2151 / 2174

页数：24

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