Direct catalytic asymmetric aldol reactions promoted by novel heterobimetallic catalysts possessing strong Bronsted base: a new strategy for the development of Lewis acid-Bronsted base bifunctional catalysts

被引：59

作者：

Yoshikawa, N ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON | 2001年 / 57卷 / 13期

基金：

日本学术振兴会;

关键词：

direct catalytic asymmetric aldol reaction; lanthanide; heterobimetallic multifunctional catalyst;

D O I：

10.1016/S0040-4020(01)00070-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel heterobimetallic catalysts possessing lithium alkoxide as Bronsted base have been developed. The catalysts were found to be effective in the direct asymmetric aldol reaction of less acidic dialkyl ketones as well as aromatic ketones, affording the aldol products in moderate yield and ee. Attempts at diastereo- and enantioselective direct catalytic aldol reaction of ethyl ketone using small molecule catalysts are reported for the first time. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：2569 / 2579

页数：11

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