Room temperature and phosphine free palladium catalyzed direct C-2 arylation of indoles

被引：405

作者：

Lebrasseur, Nathalie ^{[1
]}

Larrosa, Igor ^{[1
]}

机构：

[1] Queen Mary Univ London, Sch Biol & Chem Sci, London E1 4NS, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 10期

关键词：

D O I：

10.1021/ja710731a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first room-temperature direct C-2 arylation of indoles with iodoarenes by using a highly electrophilic palladium catalyst generated in situ from Pd(OAc)(2) and a silver carboxylate. These mild conditions permit a broad set of functionalities both in the indole and in the aryl iodide units such as free alcohols, phenols, aldehydes, bromides, or nitriles, thus allowing the synthesis of a variety of novel compounds in excellent yields.

引用

页码：2926 / 2927

页数：2

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