Elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve

Objective: To investigate the association between elevated body mass index (BMI) and ovarian reserve. Design: Cross-sectional study. Setting: Academic institutions. Patient(s): Two hundred ninety women with infertility. Diminished ovarian reserve (DOR) was defined as day 3 FSH > 10 IU/L. Intervention(s): None. Main Outcome Measure(s): Random serum antimullerian hormone (AMH) levels and number of oocytes retrieved during assisted reproductive technology cycle. Result(s): Increasing BMI was associated with lower random serum AMH levels in infertile women with DOR but not in women with normal ovarian reserve (NOR). Among women with DOR, mean random serum AMH levels were 33% lower in overweight and obese women compared with women with normal weight. The same association was not true for women with NOR. Out of 290 women evaluated for infertility, 109 women underwent a controlled ovarian hyperstimulation (COH)-IVF cycle. Women with elevated BMI and DOR had lower number of oocytes retrieved compared with women with normal BMI and DOR (6.4 +/- 4.3 vs. 9.4 +/- 6), an association that was not observed among women with NOR. Conclusion(s): Overweight and obese women with DOR as defined by high day 3 serum FSH levels have lower serum AMH levels and number of oocytes retrieved compared with nonobese women with DOR. (Fertil Steril (R) 2011; 95: 2364-8. (C) 2011 by American Society for Reproductive Medicine.)