Alzheimer's Genetics in the GWAS Era: A Continuing Story of 'Replications and Refutations'

被引：23

作者：

Bertram, Lars ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, Dept Vertebrate Genom, Neuropsychiat Genet Grp, D-14195 Berlin, Germany

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2011年 / 11卷 / 03期

关键词：

Alzheimer's disease; Causal genes; Risk genes; Susceptibility factors; Genome-wide association study; Meta-analysis; Complex genetics; GENOME-WIDE ASSOCIATION; COMPLEMENT RECEPTOR 1; IDENTIFIES VARIANTS; DISEASE; SUSCEPTIBILITY; MUTATIONS; GENES; LOCUS; RISK; APOE;

D O I：

10.1007/s11910-011-0193-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

After a decade of intensive investigation but only few replicable results, Alzheimer's disease (AD) genetics research is slowly picking up pace. This is mostly owing to the completion of several genome-wide association studies (GWAS), which have suggested the existence of over three dozen potential new AD susceptibility genes. Although only a handful of these could be confirmed in subsequent independent replication efforts to date, this success rate is still much higher than in the pre-GWAS era. This review provides a brief summary of the principal methodologic advances in genetics research of the past decade, followed by a description of the most compelling findings that these advances have unearthed in AD. The paper closes with a discussion of the persistent methodologic difficulties and challenges and an outlook on what we can expect to gain from the next 10 years of AD genetics research.

引用

页码：246 / 253

页数：8

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