Biomimetic multicomponent polysaccharide/nano-hydroxyapatite composites for bone tissue engineering

被引：106

作者：

Li, Junjie ^{[1
,2
,4
]}

Sun, Hong ^{[3
]}

Sun, Da ^{[1
,2
]}

Yao, Yuli ^{[3
]}

Yao, Fanglian ^{[1
,2
]}

Yao, Kangde ^{[4
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Minist Educ, Dept Polymer Sci, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Sch Chem Engn & Technol, Minist Educ, Key Lab Syst Bioengn, Tianjin 300072, Peoples R China

[3] N China Coal Med Coll, Dept Basic Med Sci, Tangshan 063000, Peoples R China

[4] Tianjin Univ, Res Inst Polymer Mat, Tianjin 300072, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2011年 / 85卷 / 04期

关键词：

Polysaccharide; Multicomponent; Nano-hydroxyapatite; Scaffold; Bone tissue engineering; IN-VITRO; BIOMEDICAL APPLICATIONS; CHITOSAN SCAFFOLDS; GELATIN; CELLS; DIFFERENTIATION; REGENERATION; OSTEOBLASTS; MEMBRANES; CARTILAGE;

D O I：

10.1016/j.carbpol.2011.04.015

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Nano-hydroxyapatite/chitosan-pectin (nHCP) composite was prepared via mineralization of a chitosan-pectin network. Then nHCP/chitosan-gelatin (nHCP/CG) scaffolds were prepared via the blending of nHCP and chitosan-gelatin solution. Results suggested that nHCP/CG scaffolds have appropriate porosity, water absorption ability and degradation behaviors. nHCP can be fused into the pore wall of nHCP/CG scaffold via chemical crosslinking interactions, which avoids the agglomeration and migration of nHA particles. Moreover, the compressive strength of nHCP/CG scaffold ranges from 10.4 +/- 1.64 to 13.5 +/- 3.85 MPa. nHCP/CG scaffolds have stable physical and chemical structures, which can provide appropriate microenvironments for cells to attach and proliferate for MC 3T3-E1 cells. Therefore, nHCG/CG is a potential biomaterial in bone tissue engineering. (C) 2011 Published by Elsevier Ltd.

引用

页码：885 / 894

页数：10

共 34 条

[1]

Preparation and characterization of homogeneous chitosan-polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties [J].