Role of peroxisome proliferator -: Activated receptor-γ in the glucose-sensing apparatus of liver and β-cells

被引：142

作者：

Kim, H

Ahn, Y

机构：

[1] Yonsei Univ, Dept Biochem & Mol Biol, Ctr Chron Metab Dis Res, Coll Med, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Brain Korea 21 Project Med Sci, Seoul 120749, South Korea

来源：

DIABETES | 2004年 / 53卷

关键词：

D O I：

10.2337/diabetes.53.2007.S60

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes develops in the context of both insulin resistance and beta-cell failure. Thiazolidinediones are a class of antidiabetic agents that are known to improve insulin sensitivity in various animal models of diabetes. The improved insulin sensitivity may be achieved either by systemic insulin sensitization or by direct action of peroxisome proliferator-activated receptor (PPAR)-gamma on the transcription of genes involved in glucose disposal. Evidence supporting the direct action of PPAR-gamma on glucose metabolism is observed in the genes involved in insulin-stimulated glucose disposal. We already showed that GLUT2 and beta-glucokinase were directly activated by PPAR-gamma. Recently, we have identified and characterized the functional PPAR response element in the GLUT2 and liver type glucokinase (LGK) promoter of the liver. It is well known that adipose tissue plays a crucial role in antidiabetic action of PPAR-gamma. In addition, PPAR-gamma can directly affect liver and pancreatic beta-cells to improve glucose homeostasis. Diabetes 53 (Suppl. 1):S60-S65, 2004.

引用

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页码：S60 / S65

页数：6

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