Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease

被引：93

作者：

Jessen, F ^{[1
]}

Kucharski, C ^{[1
]}

Fries, T ^{[1
]}

Papassotiropoulos, A ^{[1
]}

Hoenig, K ^{[1
]}

Maier, W ^{[1
]}

Heun, R ^{[1
]}

机构：

[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2001年 / 158卷 / 08期

关键词：

D O I：

10.1176/appi.ajp.158.8.1319

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective. Disturbed sensory gating has been related to attention deficit and greater distractibility in patients with schizophrenia, and dysfunction of the alpha-7 subunit of the cholinergic nicotinic receptor has been discussed as its biological basis. Alzheimer's disease is characterized by a cholinergic deficit, and postmortem studies have reported alpha-7 receptor loss in patients with Alzheimer's disease. in this study, the authors tested whether sensory gating is disturbed in patients with Alzheimer's disease. Method: Suppression of the P50 event-related potential following the second click of a double-click paradigm, a measure of sensory gating, was assessed in 17 Alzheimer's disease patients and 17 comparison subjects. Results: Alzheimer's disease patients showed less P50 suppression following the second click relative to the comparison subjects. Conclusions. Disturbed sensory gating might result from cholinergic dysfunction and possibly from alpha-7 nicotinic receptor loss in patients with Alzheimer's disease. Prospective studies should investigate the relationship between sensory gating deficit and behavioral disturbances in Alzheimer's disease patients.

引用

页码：1319 / 1321

页数：3

共 12 条

[1] MIDLATENCY AUDITORY EVOKED-RESPONSES - DIFFERENTIAL ABNORMALITY OF P1 IN ALZHEIMERS-DISEASE [J].