Layer-by-Layer Assembly Through Weak Interactions and Their Biomedical Applications

被引:152
作者
Matsusaki, Michiya [1 ,2 ]
Ajiro, Hiroharu [1 ]
Kida, Toshiyuki [1 ]
Serizawa, Takeshi [3 ]
Akashi, Mitsuru [1 ]
机构
[1] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
[2] Japan Sci & Technol Agcy JST, PRESTO, Saitama, Japan
[3] Univ Tokyo, Res Ctr Adv Sci & Technol RCAST, Meguro Ku, Tokyo 1538904, Japan
关键词
layer-by-Layer assembly; van der waals interactions; biological recognition; stereocomplex multilayers; fibronectin multilayers; ISOTACTIC POLY(METHYL METHACRYLATE); ENANTIOMERIC POLY(LACTIC ACID)S; MULTILAYER THIN-FILMS; STEREOCOMPLEX FORMATION; NITRIC-OXIDE; CARBON NANOTUBES; IN-SITU; TEMPLATE POLYMERIZATION; MORPHOLOGICAL-CHANGES; EXTRACELLULAR-MATRIX;
D O I
10.1002/adma.201103698
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The surface design and control of substrates with nanometer- or micrometer-sized polymer films are of considerable interest for both fundamental and applied studies in the biomedical field because of the required surface properties. The layer-by-layer (LbL) technique was discovered in 1991 by Decher and co-workers for the fabrication of polymer multilayers constructed mainly through electrostatic interaction. The scope and applicability of this LbL assembly has been extended by introducing molecularly regular conformations of polymers or proteins by employing, for the first time, weak interactions such as van der Waals interactions and biological recognition. Since these weak interactions are the sum of the attractive or repulsive forces between parts of the same molecule, they allow macromolecules to be easily arranged into the most stable conformation in a LbL film. By applying this characteristic feature, the template polymerization of stereoregular polymers, stereoregular control of surface biological properties, drastic morphological control of biodegradable nano materials, and the development of three-dimensional cellular multilayers as a tissue model were successfully achieved. It is expected that LbL assembly using weak interactions will promote further interest into fundamental and applied studies on the design of surface chemistry in the biomedical field.
引用
收藏
页码:454 / 474
页数:21
相关论文
共 187 条
[1]   Methacrylic acid and methyl methacrylate oligomers adsorbed to porous isotactic poly(methyl methacrylate) ultrathin films and mechanistic studies of living template polymerization [J].
Ajiro, Hiroharu ;
Kamei, Daisuke ;
Akashi, Mitsuru .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2008, 46 (17) :5879-5886
[2]   Thermal Stability of Porous it-PMMA Thin Film Obtained by the Extraction of st-PMAA from it-PMMA/st-PMAA Stereocomplex with Layer-by-Layer Assembly on a Substrate [J].
Ajiro, Hiroharu ;
Maegawa, Masumi ;
Akashi, Mitsuru .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2010, 48 (15) :3265-3270
[3]   Mechanistic Studies on Template Polymerization in Porous Isotactic Poly(methyl methacrylate) Thin Films by Radical Polymerization and Postpolymerization of Methacrylate Derivatives [J].
Ajiro, Hiroharu ;
Kamei, Daisuke ;
Akashi, Mitsuru .
MACROMOLECULES, 2009, 42 (08) :3019-3025
[4]   Macroporous Silicagel Substrate for Stereoregular Template Polymerization of Methacrylic Acid Using Stereocomplex Assembled Thin Films [J].
Ajiro, Hiroharu ;
Kamei, Daisuke ;
Akashi, Mitsuru .
POLYMER JOURNAL, 2009, 41 (01) :90-93
[5]   Exploring the Heteroatom Effect on Polyelectrolyte Multilayer Assembly: The Neglected Polyoniums [J].
Al-Hariri, Lara A. ;
Reisch, Andreas ;
Schlenoff, Joseph B. .
LANGMUIR, 2011, 27 (07) :3914-3919
[6]   Nitric oxide synthases: structure, function and inhibition [J].
Alderton, WK ;
Cooper, CE ;
Knowles, RG .
BIOCHEMICAL JOURNAL, 2001, 357 (03) :593-615
[7]   Controlling structure from the bottom-up: Structural and optical properties of layer-by-layer assembled palladium coordination-based multilayers [J].
Altman, Marc ;
Shukla, Atindra D. ;
Zubkov, Tatiana ;
Evmenenko, Guennadi ;
Dutta, Pulak ;
van der Boom, Milko E. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (22) :7374-7382
[8]   Biocompatible and Highly Sensitive Nitric Oxide Sensor Particles Prepared by Layer-by-layer Assembly [J].
Amemori, Suzuka ;
Matsusaki, Michiya ;
Akashi, Mitsuru .
CHEMISTRY LETTERS, 2010, 39 (01) :42-43
[9]   Inkjet Deposition of Layer-by-Layer Assembled Films [J].
Andres, Christine M. ;
Kotov, Nicholas A. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (41) :14496-14502
[10]  
[Anonymous], 2003, Organic Chemistry: Structure and Reactivity