Retinal cell fate determination and bHLH factors

被引：203

作者：

Hatakeyama, J ^{[1
]}

Kageyama, R ^{[1
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 01期

基金：

日本学术振兴会;

关键词：

bHLH; gliogenesis; homeodomain; neurogenesis; progenitor;

D O I：

10.1016/j.semcdb.2003.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Retinal development is controlled antagonistically by multiple basic helix-loop-helix (bHLH) transcriptional activators and repressors. bHLH repressors suppress bHLH activators and promote maintenance of progenitors and generation of glial cells. In contrast, bHLH activators override activities of bHLH repressors and promote neuronal differentiation. However, bHLH activators alone are not sufficient but homeodomain factors are additionally required for neuronal subtype specification. It is likely that homeodomain factors regulate the layer specificity but not the neuronal fate while bHLH activators determine the neuronal fate within the homedomain factor-specified layers. Thus, combinations of proper bHLH and homeodomain factors are required for neuronal subtype specification. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：83 / 89

页数：7

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