A new class of biodegradable thermosensitive polymers. I. Synthesis and characterization of poly(organophosphazenes) with methoxy-poly(ethylene glycol) and amino acid esters as side groups

被引：118

作者：

Song, SC

Lee, SB

Jin, JI

Sohn, YS ^{[1
]}

机构：

[1] KIST, Inorgan Chem Lab, Seoul 130650, South Korea

[2] Korea Univ, Dept Chem, Seoul 136701, South Korea

来源：

MACROMOLECULES | 1999年 / 32卷 / 07期

关键词：

D O I：

10.1021/ma981190p

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel thermosensitive poly(organophosphazenes) bearing methoxy-poly(ethylene glycol) (MPEG) and amino acid esters as substituents have been synthesized, and their lower critical solution temperature (LCST) was investigated. Differential scanning calorimetry (DSC) has shown that some of the polymers exhibit crystallinity, which is probably induced by the MPEG side chain of the polymers. Most of the polymers show their LCSTs in the range of 25.0-98.5 degrees C, depending on several factors such as mole ratio of the substituents, molecular weight of the MPEG, and kinds of amino acids and esters. The more hydrophilic composition of the polymers offers the higher LCST. The LCST of the polymers exhibits almost concentration-independent behavior in the range of 3-30 wt % of the polymers in aqueous solution.

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页码：2188 / 2193

页数：6

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