Fast-melting tablets based on highly plastic granules

被引：30

作者：

Fu, YR

Jeong, SH

Park, K

机构：

[1] Akina Inc, W Lafayette, IN 47906 USA

[2] Purdue Univ, Sch Pharm, Dept Pharmaceut, W Lafayette, IN 47907 USA

[3] Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47907 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2005年 / 109卷 / 1-3期

关键词：

highly plastic granules; fast-melting tablets; wet granulation; plastic deformation; compression; compressibility;

D O I：

10.1016/j.jconrel.2005.09.021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder. One of the unique properties of the highly plastic granules is that they maintain a porous structure even after compression into tablets. The porous and plastic nature of the granules allows fast absorption of water into the compressed tablet for fast melting/dissolution of the tablet. The prepared tablets possess tablet strength and friability that are suitable for multi-tablet packages. The three-component highly plastic granules provide an effective way of making FMTs by compression. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：203 / 210

页数：8

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