Chemoenzymatic enantioselective synthesis of (-)-indolizidine 167 B

被引：28

作者：

Chênevert, R ^{[1
]}

Ziarani, GM ^{[1
]}

Dasser, M ^{[1
]}

机构：

[1] Univ Laval, Fac Sci & Genie, Dept Chim, Quebec City, PQ G1K 7P4, Canada

来源：

HETEROCYCLES | 1999年 / 51卷 / 03期

关键词：

D O I：

10.3987/COM-98-8421

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(5R, 9R)-(-)-Indolizidine 167 B was synthesized in 8 steps from N-benzyloxycarbonyl-cis-2(R)-acetoxymethyl-6(S)-hydroxymethylpiperidine (2) in an overall yield of 60%. This starting material was obtained from enzymatic desymmetrization of the corresponding meso diacetate (1).

引用

页码：593 / 598

页数：6

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