Candida glabrata is an emerging cause of oropharyngeal candidiasis in patients receiving radiation for head and neck cancer

被引:55
作者
Redding, SW
Dahiya, MC
Kirkpatrick, WR
Coco, BJ
Patterson, TF
Fothergill, AW
Rinaldi, MG
Thomas, CR
机构
[1] Univ Texas, Hlth Sci Ctr, S Texas Vet Healthcare Syst, Dept Gen Dent, San Antonio, TX 78229 USA
[2] Univ Texas, Hlth Sci Ctr, S Texas Vet Healthcare Syst, Dept Radiat Oncol, San Antonio, TX 78229 USA
[3] Univ Texas, Hlth Sci Ctr, S Texas Vet Healthcare Syst, Dept Med, San Antonio, TX 78229 USA
[4] Univ Texas, Hlth Sci Ctr, S Texas Vet Healthcare Syst, Dept Pathol, San Antonio, TX 78229 USA
来源
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | 2004年 / 97卷 / 01期
关键词
D O I
10.1016/j.tripleo.2003.09.008
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Oropharyngeal candidiasis (OPC) is relatively common in patients receiving radiation for head and neck cancer occurring in approximately 25% of patients. Candida albicans has been described as the primary infecting organism. Recently, other organisms, particularly Candida glabrata, have emerged as causative agents of OPC among immunocompromised patients. This study describes the characteristics of 6 patients with head and neck cancer treated with radiotherapy at our institution, who were found to have Candida glabrata-associated OPC and their responses to oral fluconazole. All 6 patients were successfully treated with oral fluconazole. However, most did not respond to the usual dose of 100 mg/day necessitating doses ranging from 200 to 800 mg/day to achieve clinical cure. All 3 patients receiving radiation only,were successfully treated with up to 200 mg/day; 2 of 3 patients receiving concomitant chemoradiation required doses ranging from 400 to 800 mg/day. As with systemic infection, previous fluconazole use appears to be a risk factor for this infection, but not with all patients.
引用
收藏
页码:47 / 52
页数:6
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