The influence of nitroglycerin and prostaglandin E1 on dynamic cerebral autoregulation in adult patients during propofol and fentanyl anaesthesia

被引：12

作者：

Endoh, H ^{[1
]}

Honda, T ^{[1
]}

Ohashi, S ^{[1
]}

Hida, S ^{[1
]}

Shibue, C ^{[1
]}

Komura, N ^{[1
]}

机构：

[1] Niigata Univ, Fac Med, Niigata 9518520, Japan

来源：

ANAESTHESIA | 2001年 / 56卷 / 10期

关键词：

anaesthetics; intravenous; propofol; fentanyl; blood pressure : hypotension; measurement techniques : Doppler ultrasound; pharmacology; nitroglycerin; prostaglandin E;

D O I：

10.1046/j.1365-2044.2001.02225.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

We investigated dynamic cerebral autoregulation in 24 normocapnic adult patients during propofol and fentanyl anaesthesia. Hypotension was induced, to a mean arterial pressure (MAP) of 60-65 mmHg, using nitroglycerin or prostaglandin El. Time-averaged mean cerebral blood flow velocity in the right middle cerebral artery was measured continuously using transcranial Doppler sonography. Dynamic autoregulatory response was activated by a sudden decrease in MAP following release of bilateral thigh cuffs (thigh cuff test) and evaluated as a dynamic rate of autoregulation (dRoR in %.s(-1)). The cuff test was repeated to obtain two values of dRoR during baseline and during induced hypotension; the data were then averaged. The mean value of dRoR during baseline and during induced hypotension was 14.2 (2.9) and 14.2 (1.6) %.s(-1), respectively, in the nitroglycerin group, and 14.6 (2.6) and 14.4 (2.4) %.s(-1), in the prostaglandin E-1 group. We were unable to demonstrate significant between- or within-group differences in dRoR. Thus, we conclude that nitroglycerin and prostaglandin E-1 do not attenuate dynamic cerebral autoregulation.

引用

页码：947 / 952

页数：6

共 27 条

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