Chip calorimetry and its use for biochemical and cell biological investigations

被引：54

作者：

Lerchner, Johannes ^{[1
]}

Maskow, Thomas ^{[2
]}

Wolf, Gert ^{[1
]}

机构：

[1] Tech Univ Bergakad Freiberg, Inst Phys Chem, D-09596 Freiberg, Germany

[2] UFZ Helmholtz Ctr Environm Res, Dept Environm Microbiol, D-04318 Leipzig, Germany

来源：

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION | 2008年 / 47卷 / 06期

关键词：

chip calorimeter; biothermodynamics; metabolic heat; enzyme activity; bioreactor;

D O I：

10.1016/j.cep.2007.02.014

中图分类号：

TE [石油、天然气工业]; TK [能源与动力工程];

学科分类号：

0807 [动力工程及工程热物理]; 0820 [石油与天然气工程];

摘要：

The presented paper analyzes the potential of chip calorimetry for biochemical and cell biological investigations. From the thereto-physical properties of the heat power detectors of a chip calorimeter can be deduced that relevant applications mainly refer to fast reactions in extremely small samples. In contrast, the use of chip calorimeters for studying slow processes such as biochemical or microbial reactions is restricted. However, careful optimization of chip calorimeters concerning signal resolution and sample volume enables the investigation of enzymatically catalyzed reactions and the measurement of microbial growth heat as subsequently demonstrated with some typical examples from the literature. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：991 / 999

页数：9

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