Obesity-related hypertension: Epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue

被引：60

作者：

Aghamohammadzadeh, Reza ^{[2
,3
]}

Heagerty, Anthony M. ^{[1
,2
,3
]}

机构：

[1] Univ Manchester, Core Technol Facil, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England

[2] British Heart Fdn, London, England

[3] Manchester Wellcome Trust Clin Res Facil, Manchester, Lancs, England

来源：

ANNALS OF MEDICINE | 2012年 / 44卷

基金：

英国惠康基金;

关键词：

Adiponectin; bariatric surgery; hypertension; inflammation; obesity; oxidative stress; perivascular adipose tissue; sympathetic nervous system; CARDIOVASCULAR RISK-FACTORS; SYMPATHETIC-NERVOUS-SYSTEM; NITRIC-OXIDE PRODUCTION; VITAMIN-D-RECEPTOR; OXIDATIVE STRESS; BLOOD-PRESSURE; WEIGHT-LOSS; MINERALOCORTICOID RECEPTOR; INSULIN-RESISTANCE; BARIATRIC SURGERY;

D O I：

10.3109/07853890.2012.663928

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The advent of the obesity epidemic has highlighted the need to re-assess more closely the pathophysiology of obesity-related hypertension with the aim of identifying new therapies. In this article, we review the role of the renin-angiotensin-aldosterone system, sympathetic nervous system, and inflammation in relation to the pathophysiology of this condition. We also discuss the potential role of the perivascular adipose tissue in the context of obesity-related hypertension.

引用

页码：S74 / S84

页数：11

共 98 条

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Perivascular adipose tissue from human systemic and coronary vessels: the emergence of a new pharmacotherapeutic target [J].