Chain-breaking antioxidants and ferriheme-bound drugs are synergistic inhibitors of erythrocyte membrane peroxidation

被引：4

作者：

Dailly, E ^{[1
]}

Urien, S ^{[1
]}

Tillement, JP ^{[1
]}

机构：

[1] Univ Paris 12, Fac Med, Pharmacol Lab, F-94010 Creteil, France

来源：

FREE RADICAL RESEARCH | 1998年 / 28卷 / 02期

关键词：

antioxidant; peroxidation; erythrocyte; chloroquine; deferoxamine; ferriheme;

D O I：

10.3109/10715769809065805

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induced erythrocyte membrane peroxidation (EMP) is considered as an accurate model of reperfusion injuries and as such was used to investigate protective effects of various drugs. EMP was induced by an azo initiator and monitored by oxygen uptake. Both hydrophilic (ascorbic acid) and lipophilic (alpha-tocopherol, probucol, nicanartine) chain-breaking antioxidants as well as ferriheme-bound drugs (deferoxamine, chloroquine) inhibited EMP. When antioxidants and ferriheme-bound drugs were combined, synergistic effects were observed. It is proposed that ferriheme compounds which catalyse peroxide induced lipid peroxidation were blocked by deferoxamine and/or chloroquine. So these drugs inhibited at least partly the membrane peroxidation process and added their effects to the ones of chain-breaking antioxidants.

引用

页码：205 / 214

页数：10

共 30 条

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